Right-to-Left Shunt Detection

A shunt is an abnormal communication between the right and left sides of the heart or between the systemic and pulmonary vessels, allowing blood to flow directly from one circulatory system to the other. A right-to-left shunt (RLS) allows deoxygenated systemic venous blood to bypass the lungs and return to the body.

NovaSignal Platform for RLS Detection

Providing insight into the underlying causes of a stroke, enabling more informed treatment decisions.

Shunt Grade Assist

Simple assessment of bubble showers with regions of interest automatically identified

Vessel Lock

Quickly lock onto cerebrovascular signals in less than two minutes

Guided Exam

Record bubbles at rest and during Valsalva in 60 second segments

Remote Interpretation

View and interpret exams from anywhere

Patent Foramen Ovale (PFO)

A PFO is a hole between the left and right atria of the heart

Background & Prevalence

A PFO is the most common source of RLS and has been shown to have a higher prevalence in stroke patients. A PFO closure significantly reduces the rate of recurrent stroke.

25%
of the population has a PFO1
43%
of cryptogenic stroke patients have a PFO2
NovaSignal Benefit

A TCD bubble study is non-invasive and has 96% sensitivity for RLS detection.2 Understanding the underlying cause of a stroke allows physicians to make more informed decisions, ultimately leading to better patient management.

Clinical Trial Results3

NovaGuide Intelligent Ultrasound compared to standard of care TTE for RLS detection

>3X

shunt detection rate

63.6% with NovaGuide, 20.9% with TTE

2.7X

detection of intervenable shunts

27% with NovaGuide, 10% with TTE

Read the full results from this groundbreaking study

download the results
Clinical Support

TCD vs TTE for PFO Detection

Katsanos, A. H., Psaltopoulou, T., Sergentanis, T. N., Frogoudaki, A., Vrettou, A. R., Ikonomidis, I., Tsivgoulis, G. (2016). Transcranial Doppler versus transthoracic echocardiography for the detection of patent foramen ovale in patients with cryptogenic cerebral ischemia: A systematic review and diagnostic test accuracy meta-analysis. Annals of Neurology. 2016 Apr;79(4):625-35.

View Publication

TCD is Complementary to TTE

Tobe J, Bogiatzi C, Munoz C, Tamayo A, Spence JD. Transcranial Doppler is Complementary to Echocardiography for Detection and Risk Stratification of Patent. The Canadian journal of Cardiology, 2016 Aug;32(8):986.e9-986.e16.

View Publication

NovaGuide vs TTE

Rubin, M., Shah, R., et al. Novel Robotic-Assisted Transcranial Doppler versus Transthoracic Echocardiography to Detect Right-to-Left Shunts. New Orleans, LA USA: International Stroke Conference - Late Breaking Abstract.

COVID-19

COVID-19 is a complex disease that can affect multiple organ systems including the brain, heart, and lungs.

Background & Prevalence

Patients with severe COVID-19 pneumonia display high levels of vascular shunting, which is correlated with low lung compliance.4

NovaSignal Benefit

The robotic nature of NovaGuide enables autonomous monitoring and reduces contact between providers and patients with COVID-19.

NovaGuide Identifies a Different Pathophysiology of COVID-19 Pneumonia

NovaGuide detected microbubbles in 83% of mechanically ventilated patients, signaling vascular shunting4

READ THE STUDY
Clinical Support

Pulmonary Vascular Dilatation Detected by NovaGuide in COVID-19 Pneumoniaion

Reynolds AS, Lee AG, Renz J, DeSanti, K, Liang J, Powell CA, Ventetuolo CE, Poor HD. Pulmonary Vascular Dilatation Detected by Automated Transcranial Doppler in COVID-19 Pneumonia. American Journal of Respiratory and Critical Care Medicine. August 06, 2020.

View Publication

References:

  1. Ghosh AK, Jain A. Diagnosis and management of patent foramen ovale. Br J Hosp Med (Lond). 2015;76:C98–C102.
  2. Katsanos, A. H., Psaltopoulou, T., Sergentanis, T. N., Frogoudaki, A., Vrettou, A. R., Ikonomidis, I., … Tsivgoulis, G. (2016). Transcranial Doppler versus transthoracic echocardiography for the detection of patent foramen ovale in patients with cryptogenic cerebral ischemia: A systematic review and diagnostic test accuracy meta-analysis. Annals of Neurology, 79(4), 625–635. https://doi.org/10.1002/ana.24609
  3. Rubin, M., Shah, R., et al. Novel Robotic-Assisted Transcranial Doppler versus Transthoracic Echocardiography to Detect Right-to-Left Shunts. New Orleans, LA USA: International Stroke Conference - Late Breaking Abstract.
  4. Reynolds AS, Lee AG, Renz J, DeSanti, K, Liang J, Powell CA, Ventetuolo CE, Poor HD. Pulmonary Vascular Dilatation Detected by Automated Transcranial Doppler in COVID-19 Pneumonia. American Journal of Respiratory and Critical Care Medicine. August 2020.

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Emboli 
Monitoring
Perioperative
Monitoring
Embolic
Stroke
References
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